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Are There Any Medical Conditions That Prevent People From Losing Weight?

I've been trying to lose weight for years! I eat a healthy diet and am very active, but I just can't seem to lose any weight. Recently, a friend of mine suggested that I might have a medical condition that is preventing me from losing weight. Is that possible? If so, what medical condition(s) could be responsible?
 

 
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Answer

Hypothyroidism has been associated with weight gain, and if untreated, theoretically could prevent someone from losing weight. Hypothyroidism is a condition in which the body does not produce sufficient thyroid hormones. Medications are available to replace thyroid hormones in people with hypothyroidism, and people may lose weight once their condition is treated.
 
Cushing's syndrome or Cushing's disease has also been associated with obesity. Cushing's syndrome is the result of excess glucocorticoids or cortisol. Most often, Cushing's syndrome occurs because of chronic use of steroid medications, such as prednisone. Cushing's disease can also occur as a result of a pituitary or adrenal disorder, but this is rare. Weight gain in Cushing's syndrome is often due to water retention and fat deposition in the midsection and in a hump behind the neck. 
 
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